Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyl 2,3,4-Trimethoxybenzoate SCHEMBL1434191 | 0.85 | ALDH1A1 (0.57) | KDM4EPOLBALDH1A1MAPTTDP1 | |
| SCHEMBL27512581 | 0.78 | KMT2A (0.50) | KDM4EPOLBALDH1A1MAPTHSD17B10 | |
| SCHEMBL6852879 | 0.75 | CA1 (0.52) | KDM4EPOLBALDH1A1MAPTTDP1 | |
| SCHEMBL29208993 | 0.75 | MAPT (0.47) | KDM4EPOLBALDH1A1MAPTHSD17B10 | |
| SCHEMBL24136599 | 0.75 | LMNA (0.55) | KDM4EPOLBALDH1A1MAPTTDP1 | |
| SCHEMBL16513023 | 0.75 | HTT (0.50) | KDM4EPOLBALDH1A1MAPTTDP1 | |
| SCHEMBL1434290 | 0.75 | MAPT (0.71) | KDM4EPOLBALDH1A1MAPTTDP1 | |
| SCHEMBL23051546 | 0.75 | MAPT (0.51) | KDM4EPOLBALDH1A1MAPTTDP1 | |
| SCHEMBL30466421 | 0.75 | LMNA (0.55) | KDM4EPOLBALDH1A1MAPTTDP1 | |
| SCHEMBL8526786 | 0.74 | MAPT (0.55) | ALDH1A1MAPTTDP1PKMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0887344-B1 | Quinolines and quinazolines useful in therapy | PFIZER LTD (GB) | 2003-12-03 | — | — | EP | disclosed |
| US-6417194-B1 | TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | PFIZER, INC. | 2002-07-09 | — | — | US | disclosed |
| US-6048864-A | Quinolines and quinazolines useful in therapy | PFIZER INC (US) | 2000-04-11 | — | — | US | disclosed |
| EP-0887344-A1 | Quinolines and quinazolines useful in therapy | Pfizer Limited (GB) | 1998-12-30 | — | — | EP | disclosed |