Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 5/20 | 0.67 |
| ▸ | ERCC5 | P28715 | 7/20 | 0.55 |
| ▸ | FEN1 | P39748 | 7/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943441 | 0.81 | PTPN1 (1.00) | PTPN1ERCC5FEN1KMT2AL3MBTL1 | |
| Dimethylamine SCHEMBL6946035 | 0.79 | PTPN1 (0.68) | PTPN1ERCC5FEN1HAO1 | |
| SCHEMBL7196671 | 0.78 | ERCC5 (0.66) | PTPN1ERCC5FEN1KMT2AMEN1 | |
| SCHEMBL6940911 | 0.78 | PTPN1 (0.72) | PTPN1ERCC5FEN1KMT2AMEN1 | |
| SCHEMBL14700286 | 0.77 | KMT2A (0.47) | PTPN1KMT2AL3MBTL1MEN1HDAC3 | |
| SCHEMBL9433060 | 0.75 | KMT2A (0.43) | PTPN1KMT2AL3MBTL1MEN1HDAC3 | |
| SCHEMBL7665038 | 0.74 | PTPN1 (0.74) | PTPN1ERCC5FEN1KMT2AMEN1 | |
| SCHEMBL9019916 | 0.74 | KMT2A (0.41) | PTPN1KMT2AL3MBTL1MEN1HDAC3 | |
| SCHEMBL6948181 | 0.73 | PTPN1 (0.61) | PTPN1ERCC5FEN1KMT2AMEN1 | |
| SCHEMBL6946034 | 0.73 | PTPN1 (0.53) | PTPN1ERCC5FEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082121-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2003-02-05 | — | — | EP | claimed |
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | claimed |
| EP-1082121-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | claimed |
| WO-1999062520-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | claimed |
| EP-1082121-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2003-02-05 | — | — | EP | disclosed |
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | disclosed |
| EP-1082121-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999062520-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | disclosed |