Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.53 |
| ▸ | ERCC5 | P28715 | 8/20 | 0.49 |
| ▸ | FEN1 | P39748 | 8/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HAO1 | Q9UJM8 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6951641 | 0.88 | FEN1 (0.54) | PTPN1ERCC5FEN1HDAC1HDAC6 | |
| SCHEMBL6947604 | 0.85 | ERCC5 (0.61) | PTPN1ERCC5FEN1HAO1 | |
| SCHEMBL6943570 | 0.85 | PTPN1 (0.48) | PTPN1ERCC5FEN1HAO1 | |
| SCHEMBL6949748 | 0.82 | ERCC5 (0.53) | PTPN1ERCC5FEN1HAO1KMT2A | |
| SCHEMBL6948238 | 0.79 | PTPN1 (0.44) | PTPN1ERCC5FEN1HAO1 | |
| Dimethylamine SCHEMBL6946035 | 0.79 | PTPN1 (0.68) | PTPN1ERCC5FEN1HAO1 | |
| SCHEMBL6947067 | 0.78 | PTPN1 (0.53) | PTPN1ERCC5FEN1HAO1KMT2A | |
| SCHEMBL6940911 | 0.78 | PTPN1 (0.72) | PTPN1ERCC5FEN1HAO1KMT2A | |
| SCHEMBL6948235 | 0.77 | PTPN1 (0.42) | PTPN1ERCC5FEN1HAO1 | |
| SCHEMBL7667672 | 0.75 | PIM2 (0.41) | PTPN1ERCC5FEN1HAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082121-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2003-02-05 | — | — | EP | claimed |
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | claimed |
| EP-1082121-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | claimed |
| WO-1999062520-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | claimed |
| EP-1082121-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2003-02-05 | — | — | EP | disclosed |
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | disclosed |
| EP-1082121-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999062520-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | disclosed |