Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 6/20 | 1.00 |
| ▸ | ERCC5 | P28715 | 7/20 | 0.57 |
| ▸ | FEN1 | P39748 | 7/20 | 0.57 |
| ▸ | CRHBP | P24387 | 1/20 | 0.54 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.47 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6950179 | 0.84 | PTPN1 (0.72) | PTPN1ERCC5FEN1KMT2ANR3C1 | |
| SCHEMBL7403019 | 0.82 | PTPN1 (0.70) | PTPN1CRHBPCRHR2KMT2AL3MBTL1 | |
| SCHEMBL6952400 | 0.82 | PTPN1 (0.68) | PTPN1CRHBPCRHR2KMT2AL3MBTL1 | |
| SCHEMBL6945998 | 0.81 | PTPN1 (0.67) | PTPN1ERCC5FEN1CRHBPCRHR2 | |
| SCHEMBL11228424 | 0.80 | PTPN1 (0.67) | PTPN1CRHBPCRHR2KMT2AL3MBTL1 | |
| SCHEMBL22658227 | 0.79 | CRHBP (0.68) | PTPN1CRHBPCRHR2KMT2AL3MBTL1 | |
| SCHEMBL28458480 | 0.79 | PTPN1 (0.65) | PTPN1CRHBPCRHR2KMT2AL3MBTL1 | |
| SCHEMBL21377435 | 0.78 | PTPN1 (0.64) | PTPN1CRHBPCRHR2KMT2AL3MBTL1 | |
| SCHEMBL7196671 | 0.77 | ERCC5 (0.66) | PTPN1ERCC5FEN1KMT2AHAO1 | |
| SCHEMBL6940911 | 0.77 | PTPN1 (0.72) | PTPN1ERCC5FEN1KMT2AHAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082121-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2003-02-05 | — | — | EP | claimed |
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | claimed |
| EP-1082121-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | claimed |
| WO-1999062520-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | claimed |
| US-11446398-B2 | Regulated biocircuit systems | OBSIDIAN THERAPEUTICS, INC. (US) | 2022-09-20 | — | — | US | disclosed |
| US-20210254056-A1 | IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS | CAMP4 THERAPEUTICS CORPORATION | 2021-08-19 | — | — | US | disclosed |
| US-20190192691-A1 | REGULATED BIOCIRCUIT SYSTEMS | OBSIDIAN THERAPEUTICS, INC. | 2019-06-27 | — | — | US | disclosed |
| EP-1082121-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2003-02-05 | — | — | EP | disclosed |
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | disclosed |
| EP-1082121-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999062520-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | disclosed |