Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.41 |
| ▸ | ERCC5 | P28715 | 4/20 | 0.40 |
| ▸ | FEN1 | P39748 | 4/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.39 |
| ▸ | BRAF | P15056 | 5/20 | 0.38 |
| ▸ | HAO1 | Q9UJM8 | 3/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6950602 | 0.80 | ERCC5 (0.47) | PIM2ERCC5FEN1PTPN1HAO1 | |
| SCHEMBL7667601 | 0.79 | PIM2 (0.56) | PIM2PIM1 | |
| SCHEMBL6946034 | 0.75 | PTPN1 (0.53) | ERCC5FEN1PTPN1HAO1 | |
| SCHEMBL6945686 | 0.75 | ERCC5 (0.46) | ERCC5FEN1PTPN1HAO1 | |
| SCHEMBL6947604 | 0.74 | ERCC5 (0.61) | ERCC5FEN1PTPN1HAO1 | |
| SCHEMBL7073904 | 0.72 | TBXAS1 (0.52) | ERCC5FEN1PTPN1 | |
| SCHEMBL6949748 | 0.71 | ERCC5 (0.53) | ERCC5FEN1PTPN1HAO1 | |
| SCHEMBL7082801 | 0.70 | LMNA (0.44) | BRAFCYP11B1CYP11B2 | |
| SCHEMBL6949374 | 0.68 | PTPN1 (0.45) | ERCC5FEN1PTPN1HAO1 | |
| SCHEMBL6948238 | 0.68 | PTPN1 (0.44) | ERCC5FEN1PTPN1HAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | claimed |
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | disclosed |