Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 5/20 | 0.37 |
| ▸ | ACLY | P53396 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | USP5 | P45974 | 1/20 | 0.33 |
| ▸ | BCL2 | P10415 | 1/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP7 | P09237 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6941551 | 0.83 | TSHR (0.37) | MMP9RORC | |
| SCHEMBL6941549 | 0.83 | TSHR (0.37) | MMP9RORC | |
| SCHEMBL6941547 | 0.83 | TSHR (0.37) | MMP9RORC | |
| SCHEMBL6941094 | 0.77 | MMP9 (0.57) | MMP9RORCBACE1 | |
| SCHEMBL6941092 | 0.77 | MMP9 (0.57) | MMP9RORCBACE1 | |
| SCHEMBL7643692 | 0.77 | RORC (0.45) | RORC | |
| SCHEMBL6941442 | 0.77 | RORC (0.40) | MMP9RORCMMP1MMP3MMP7 | |
| SCHEMBL6936907 | 0.77 | RORC (0.40) | MMP9RORCMMP1MMP3MMP7 | |
| SCHEMBL6936904 | 0.77 | RORC (0.40) | MMP9RORCMMP1MMP3MMP7 | |
| SCHEMBL6939720 | 0.76 | MMP8 (0.53) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155013-B1 | HETEROCYCLIC BENZENESULPHONAMIDE COMPOUNDS AS BRADYKININE ANTAGONISTS | FOURNIER IND & SANTE (FR) | 2003-07-23 | — | — | EP | disclosed |
| US-6479515-B1 | FOR THE TREATMENT OF PAIN AND INFLAMMATION, AND ESPECIALLY IN THE TREATMENT OF ASTHMA, CEREBRAL TRAUMATIC SHOCK AND ALLERGIC RHINITIS | FOURNIER INDUSTRIE ET SANTE (FR) | 2002-11-12 | — | — | US | disclosed |
| EP-1155013-A1 | HETEROCYCLIC BENZENESULPHONAMIDE COMPOUNDS AS BRADYKININE ANTAGONISTS | FOURNIER INDUSTRIE ET SANTE (FR) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000050418-A9 | HETEROCYCLIC BENZENESULPHONAMIDE COMPOUNDS AS BRADYKININE ANTAGONISTS | FOURNIER IND & SANTE (FR) | 2001-02-22 | — | — | WO | disclosed |
| WO-2000050418-A1 | HETEROCYCLIC BENZENESULPHONAMIDE COMPOUNDS AS BRADYKININE ANTAGONISTS | FOURNIER INDUSTRIE ET SANTE (FR) | 2000-08-31 | — | — | WO | disclosed |