SCHEMBL6939720

SCHEMBL6939720

O=C(O)[C@@H]1CCCN1S(=O)(=O)c1ccc(Cl)c(CBr)c1Cl

nearest known ligand 0.56

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MMP8 P22894 1/20 0.53
MMP12 P39900 1/20 0.53
MMP13 P45452 1/20 0.53
RORC P51449 4/20 0.51
ALDH1A1 P00352 1/20 0.49
BDKRB2 P30411 1/20 0.48
BDKRB1 P46663 1/20 0.48
POLB P06746 1/20 0.47
HTT P42858 1/20 0.44
TSHR P16473 2/20 0.44
KDM4E B2RXH2 1/20 0.43
CASP1 P29466 1/20 0.43
CASP7 P55210 1/20 0.43
PLAU P00749 2/20 0.43
BRD4 O60885 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6944021 1.00 MMP8 (0.53) MMP8MMP12MMP13RORCALDH1A1
SCHEMBL7649083 0.96 ALDH1A1 (0.54) MMP8MMP12MMP13RORCALDH1A1
SCHEMBL7643692 0.94 RORC (0.45) MMP8MMP12MMP13RORCALDH1A1
SCHEMBL7815324 0.89 RORC (0.51) MMP8MMP12MMP13RORCALDH1A1
SCHEMBL7718792 0.86 BDKRB2 (0.49) RORCBDKRB2BDKRB1
SCHEMBL7811395 0.85 BDKRB2 (0.60) RORCBDKRB2BDKRB1
SCHEMBL6945959 0.83 RORC (0.51) RORCBDKRB2BDKRB1PLAUBRD4
SCHEMBL7650181 0.82 ALDH1A1 (0.48) MMP8MMP12MMP13RORCALDH1A1
SCHEMBL6941547 0.82 TSHR (0.37) MMP8MMP12MMP13RORCALDH1A1
SCHEMBL6941551 0.82 TSHR (0.37) MMP8MMP12MMP13RORCALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0944618-B1 NOVEL N-BENZENESULPHONYL-L-PROLINE DERIVATIVES, METHOD FOR PREPARING AND THERAPEUTIC USE FOURNIER IND & SANTE (FR) 2003-09-24 EP disclosed
EP-0991650-B1 NOVEL N-BENZENESULPHONYL-L-PROLINE COMPOUNDS, PREPARATION METHOD AND USE IN THERAPY FOURNIER IND & SANTE (FR) 2003-09-10 EP disclosed
EP-1155013-B1 HETEROCYCLIC BENZENESULPHONAMIDE COMPOUNDS AS BRADYKININE ANTAGONISTS FOURNIER IND & SANTE (FR) 2003-07-23 EP disclosed
US-6479515-B1 FOR THE TREATMENT OF PAIN AND INFLAMMATION, AND ESPECIALLY IN THE TREATMENT OF ASTHMA, CEREBRAL TRAUMATIC SHOCK AND ALLERGIC RHINITIS FOURNIER INDUSTRIE ET SANTE (FR) 2002-11-12 US disclosed
EP-1155013-A1 HETEROCYCLIC BENZENESULPHONAMIDE COMPOUNDS AS BRADYKININE ANTAGONISTS FOURNIER INDUSTRIE ET SANTE (FR) 2001-11-21 EP disclosed
EP-0787131-B1 BENZENESULPHONAMIDE DERIVATIVES AS BRADYKININE ANTAGONISTS FOURNIER IND & SANTE (FR) 2001-10-31 EP disclosed
EP-0874841-B1 1-BENZENESULFONYL PYRROLIDINE DERIVATIVES AS BRADYKININ RECEPTOR ANTAGONISTS FOURNIER IND & SANTE (FR) 2001-10-04 EP disclosed
WO-2000050418-A9 HETEROCYCLIC BENZENESULPHONAMIDE COMPOUNDS AS BRADYKININE ANTAGONISTS FOURNIER IND & SANTE (FR) 2001-02-22 WO disclosed
WO-2000050418-A1 HETEROCYCLIC BENZENESULPHONAMIDE COMPOUNDS AS BRADYKININE ANTAGONISTS FOURNIER INDUSTRIE ET SANTE (FR) 2000-08-31 WO disclosed
EP-0991650-A1 NOVEL N-BENZENESULPHONYL-L-PROLINE COMPOUNDS, PREPARATION METHOD AND USE IN THERAPY FOURNIER INDUSTRIE ET SANTE (FR) 2000-04-12 EP disclosed
EP-0944618-A1 NOVEL N-BENZENESULPHONYL-L-PROLINE DERIVATIVES, METHOD FOR PREPARING AND THERAPEUTIC USE FOURNIER INDUSTRIE ET SANTE (FR) 1999-09-29 EP disclosed
WO-1999000387-A1 NOVEL N-BENZENESULPHONYL-L-PROLINE COMPOUNDS, PREPARATION METHOD AND USE IN THERAPY FOURNIER INDUSTRIE ET SANTE (FR) 1999-01-07 WO disclosed
EP-0874841-A1 1-BENZENESULFONYL PYRROLIDINE DERIVATIVES AS BRADYKININ RECEPTOR B2 ANTAGONISTS FOURNIER INDUSTRIE ET SANTE (FR) 1998-11-04 EP disclosed
WO-1998024783-A1 NOVEL N-BENZENESULPHONYL-L-PROLINE DERIVATIVES, METHOD FOR PREPARING AND THERAPEUTIC USE FOURNIER INDUSTRIE ET SANTE (FR) 1998-06-11 WO disclosed
EP-0787131-A1 BENZENESULPHONAMIDE DERIVATIVES AS BRADYKININE ANTAGONISTS FOURNIER INDUSTRIE ET SANTE (FR) 1997-08-06 EP disclosed
WO-1997024349-A1 1-BENZENESULFONYL PYRROLIDINE DERIVATIVES AS BRADYKININ RECEPTOR ANTAGONISTS FOURNIER INDUSTRIE ET SANTE (FR) 1997-07-10 WO disclosed
WO-1997007115-A1 BENZENESULPHONAMIDE DERIVATIVES AS BRADYKININE ANTAGONISTS FOURNIER INDUSTRIE ET SANTE (FR) 1997-02-27 WO disclosed