Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6604494 | 0.82 | TNF (0.46) | TNFRAB9AALDH1A1ALOX15HSD17B10 | |
| SCHEMBL6604487 | 0.82 | TNF (0.46) | TNFRAB9AALDH1A1ALOX15HSD17B10 | |
| SCHEMBL3912571 | 0.70 | SLC6A2 (0.43) | ALDH1A1CYP1A2CYP3A4CYP2D6MAPT | |
| SCHEMBL4675885 | 0.70 | SLC6A2 (0.43) | ALDH1A1CYP1A2CYP3A4CYP2D6MAPT | |
| SCHEMBL8592939 | 0.70 | SLC6A3 (0.38) | ALDH1A1CYP3A4CYP2D6HTT | |
| SCHEMBL4712246 | 0.70 | MAPK1 (0.55) | RAB9AALDH1A1MAPTKMT2ACASP3 | |
| SCHEMBL8913116 | 0.70 | PRKCZ (0.49) | ALDH1A1CYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL18756303 | 0.69 | LTA4H (0.51) | RAB9AALDH1A1MAPTKMT2ACASP3 | |
| SCHEMBL18222526 | 0.69 | ALDH1A1 (0.49) | TNFRAB9AALDH1A1MAPTKMT2A | |
| SCHEMBL7260089 | 0.69 | ALDH1A1 (0.49) | TNFRAB9AALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709376-B1 | Phenylpiperidino derivatives as neurokinin antagonists | ASTRAZENECA AB (SE) | 2003-07-23 | — | — | EP | disclosed |
| US-6008223-A | ANTIINFLAMMATORY AGENTS FOR TREATING ASTHMA | ZENECA LIMITED (GB) | 1999-12-28 | — | — | US | disclosed |
| US-5731309-A | Substituted heteroalkyleneamine neurokinin antagonists | ZENECA LIMITED (GB) | 1998-03-24 | — | — | US | disclosed |
| EP-0709376-A2 | Therapeutic compounds | ZENECA LIMITED (GB) | 1996-05-01 | — | — | EP | disclosed |