Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.58 |
| ▸ | RAB9A | P51151 | 7/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | TACR3 | P29371 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | CLK1 | P49759 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.55 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.55 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.55 |
| ▸ | APP | P05067 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2124884 | 0.81 | NPC1 (0.59) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL17554077 | 0.79 | SMN1; SMN2 (0.70) | NPC1RAB9AKMT2AMEN1TACR3 | |
| SCHEMBL7705937 | 0.77 | ALDH1A1 (0.76) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL3102721 | 0.77 | MTNR1A (0.57) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL3236742 | 0.76 | ALDH1A1 (0.62) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL28341413 | 0.76 | RAB9A (0.76) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL30560618 | 0.76 | NPC1 (0.57) | NPC1RAB9AKMT2AMEN1TACR3 | |
| SCHEMBL17554153 | 0.76 | NPC1 (0.57) | NPC1RAB9AKMT2AMEN1TACR3 | |
| SCHEMBL17554032 | 0.76 | RAB9A (0.64) | NPC1RAB9AKMT2AMEN1TACR3 | |
| SCHEMBL6946739 | 0.75 | MEN1 (0.58) | KMT2AMEN1KDM4ESLC6A5GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674623-B1 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-04-09 | — | — | EP | disclosed |
| US-6403578-B1 | ANTICOAGULANTS, CARDIOVASCULAR DISORDERS | SMITHKLINE BEECHAM CORPORATION | 2002-06-11 | — | — | US | disclosed |
| EP-0674623-A1 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994014776-A2 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-07-07 | — | — | WO | disclosed |