Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 4/20 | 0.44 |
| ▸ | MMP1 | P03956 | 3/20 | 0.44 |
| ▸ | MMP3 | P08254 | 7/20 | 0.44 |
| ▸ | MMP2 | P08253 | 5/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6956564 | 0.89 | KDM4E (0.43) | HSD17B10KDM4ECYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6956557 | 0.87 | MMP9 (0.58) | MMP9MMP1MMP3MMP2MMP8 | |
| SCHEMBL7384509 | 0.86 | MME (0.45) | HSD17B10KDM4ECYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6419064 | 0.85 | MMP3 (0.46) | HSD17B10KDM4ECYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6951780 | 0.82 | MMP3 (0.46) | HSD17B10MMP9MMP1MMP3MMP2 | |
| SCHEMBL6953223 | 0.81 | MMP3 (0.63) | MMP9MMP1MMP3MMP2MMP8 | |
| SCHEMBL6953525 | 0.80 | MME (0.57) | MMP9MMP1MMP3MMP2 | |
| SCHEMBL6950472 | 0.80 | MAPT (0.52) | HSD17B10KDM4ECYP3A4MMP9MMP1 | |
| SCHEMBL8651860 | 0.78 | MMP3 (0.54) | KDM4EMMP9MMP1MMP3MMP2 | |
| SCHEMBL8385864 | 0.77 | MMP3 (0.42) | HSD17B10KDM4ECYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824544-B1 | PEPTIDYL COMPOUNDS WHICH INHIBIT METALLOPROTEINASE AND TNF LIBERATION AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-04-16 | — | — | EP | claimed |
| EP-0824544-A1 | PEPTIDYL COMPOUNDS WHICH INHIBIT METALLOPROTEINASE AND TNF LIBERATION AND THEIR THERAPEUTIC USE | Chiroscience Limited (GB) | 1998-02-25 | — | — | EP | claimed |
| WO-1996035712-A1 | PEPTIDYL COMPOUNDS WHICH INHIBIT METALLOPROTEINASE AND TNF LIBERATION AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-14 | — | — | WO | claimed |
| EP-0824544-B1 | PEPTIDYL COMPOUNDS WHICH INHIBIT METALLOPROTEINASE AND TNF LIBERATION AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-04-16 | — | — | EP | disclosed |
| US-5994293-A | Peptidyl compounds and their therapeutic use | DARWIN DISCOVERY LTD. (GB) | 1999-11-30 | — | — | US | disclosed |