Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | NMBR | P28336 | 4/20 | 0.47 |
| ▸ | TACR1 | P25103 | 1/20 | 0.47 |
| ▸ | TACR3 | P29371 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CTSC | P53634 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947785 | 0.90 | MEN1 (0.47) | MAPTTDP1NMBRTACR1MEN1 | |
| SCHEMBL6953189 | 0.90 | MEN1 (0.55) | MAPTTDP1MEN1KMT2ANPC1 | |
| SCHEMBL6950472 | 0.89 | MAPT (0.52) | MAPTTDP1NMBRTACR1TACR3 | |
| SCHEMBL7895260 | 0.87 | MMP1 (0.56) | MMP2MMP8MMP9MMP1 | |
| SCHEMBL6412675 | 0.87 | MMP1 (0.56) | MMP2MMP8MMP9MMP1 | |
| SCHEMBL7894297 | 0.87 | MMP1 (0.56) | MMP2MMP8MMP9MMP1 | |
| SCHEMBL6947712 | 0.85 | MMP1 (0.55) | RAB9AMMP2MMP8MMP9MMP1 | |
| SCHEMBL6944864 | 0.84 | MMP3 (0.46) | NPC1GAAMMP2MMP9MMP1 | |
| SCHEMBL6956564 | 0.82 | KDM4E (0.43) | MEN1KMT2ANPC1ALDH1A1KDM4E | |
| SCHEMBL6956115 | 0.81 | MMP3 (0.44) | MEN1KMT2ANPC1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824544-B1 | PEPTIDYL COMPOUNDS WHICH INHIBIT METALLOPROTEINASE AND TNF LIBERATION AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-04-16 | — | — | EP | claimed |
| EP-0824544-B1 | PEPTIDYL COMPOUNDS WHICH INHIBIT METALLOPROTEINASE AND TNF LIBERATION AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-04-16 | — | — | EP | disclosed |
| US-5994293-A | Peptidyl compounds and their therapeutic use | DARWIN DISCOVERY LTD. (GB) | 1999-11-30 | — | — | US | disclosed |