Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 11/20 | 0.44 |
| ▸ | MMP1 | P03956 | 6/20 | 0.44 |
| ▸ | MMP2 | P08253 | 8/20 | 0.42 |
| ▸ | MMP9 | P14780 | 6/20 | 0.42 |
| ▸ | MMP7 | P09237 | 2/20 | 0.42 |
| ▸ | MMP14 | P50281 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6944864 | 0.89 | MMP3 (0.46) | MMP3MMP1MMP2MMP9MMP7 | |
| SCHEMBL8764282 | 0.89 | MMP3 (0.43) | MMP3MMP1MMP2MMP9MMP7 | |
| SCHEMBL6414900 | 0.88 | MMP3 (0.47) | MMP3MMP1MMP2MMP9MMP7 | |
| SCHEMBL6951780 | 0.88 | MMP3 (0.46) | MMP3MMP1MMP2MMP9MMP7 | |
| SCHEMBL6947712 | 0.87 | MMP1 (0.55) | MMP3MMP1MMP2MMP9MMP7 | |
| SCHEMBL7452724 | 0.84 | MMP1 (0.48) | MMP3MMP1MMP2MMP9MMP7 | |
| SCHEMBL6948615 | 0.84 | MMP1 (0.48) | MMP3MMP1MMP2MMP9MMP7 | |
| SCHEMBL6956564 | 0.84 | KDM4E (0.43) | MMP3MMP1MMP2MMP9MMP7 | |
| SCHEMBL6950677 | 0.84 | MMP9 (0.60) | MMP3MMP1MMP2MMP9MEN1 | |
| SCHEMBL6953482 | 0.82 | ALDH1A1 (0.49) | MMP3MMP1MMP2MMP9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824544-B1 | PEPTIDYL COMPOUNDS WHICH INHIBIT METALLOPROTEINASE AND TNF LIBERATION AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-04-16 | — | — | EP | claimed |
| EP-0824544-B1 | PEPTIDYL COMPOUNDS WHICH INHIBIT METALLOPROTEINASE AND TNF LIBERATION AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-04-16 | — | — | EP | disclosed |
| US-5994293-A | Peptidyl compounds and their therapeutic use | DARWIN DISCOVERY LTD. (GB) | 1999-11-30 | — | — | US | disclosed |