Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 8/20 | 0.37 |
| ▸ | MMP9 | P14780 | 8/20 | 0.37 |
| ▸ | MMP13 | P45452 | 7/20 | 0.37 |
| ▸ | MMP3 | P08254 | 7/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 7/20 | 0.32 |
| ▸ | MMP8 | P22894 | 5/20 | 0.32 |
| ▸ | MMP7 | P09237 | 2/20 | 0.31 |
| ▸ | MMP14 | P50281 | 2/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6948470 | 0.90 | MMP2 (0.30) | MMP2MMP9MMP13MMP3MMP1 | |
| SCHEMBL6946816 | 0.87 | MMP13 (0.40) | MMP2MMP9MMP13MMP3CA1 | |
| SCHEMBL6953868 | 0.77 | MMP2 (0.32) | MMP2MMP9MMP13MMP3CA2 | |
| SCHEMBL6952757 | 0.74 | MMP3 (0.48) | MMP2MMP9MMP13MMP3MMP1 | |
| SCHEMBL6943088 | 0.73 | MMP2 (0.49) | MMP2MMP9MMP13MMP3MMP1 | |
| SCHEMBL6943124 | 0.72 | MMP2 (0.54) | MMP2MMP9MMP13MMP3MMP1 | |
| SCHEMBL6949235 | 0.71 | MMP2 (0.43) | MMP2MMP9MMP13MMP3MMP1 | |
| SCHEMBL6946800 | 0.71 | MMP2 (0.49) | MMP2MMP9MMP13MMP3MMP1 | |
| SCHEMBL6943165 | 0.69 | MMP3 (0.46) | MMP2MMP9MMP13MMP3MMP1 | |
| SCHEMBL6948783 | 0.67 | MMP13 (0.47) | MMP2MMP9MMP13MMP3MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030836-B1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LTD (GB) | 2003-01-29 | — | — | EP | claimed |