Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 13/20 | 0.47 |
| ▸ | MMP3 | P08254 | 13/20 | 0.47 |
| ▸ | MMP1 | P03956 | 13/20 | 0.47 |
| ▸ | MMP2 | P08253 | 12/20 | 0.47 |
| ▸ | MMP8 | P22894 | 9/20 | 0.47 |
| ▸ | MMP9 | P14780 | 8/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.47 |
| ▸ | MMP7 | P09237 | 2/20 | 0.47 |
| ▸ | MMP14 | P50281 | 2/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.32 |
| ▸ | BMP1 | P13497 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7077621 | 0.90 | MMP2 (0.40) | MMP13MMP3MMP1MMP2MMP8 | |
| SCHEMBL6948807 | 0.79 | MMP3 (0.49) | MMP13MMP3MMP1MMP2MMP8 | |
| SCHEMBL6947014 | 0.76 | MMP2 (0.49) | MMP13MMP3MMP1MMP2MMP8 | |
| SCHEMBL6948780 | 0.76 | MMP13 (0.43) | MMP13MMP3MMP1MMP2MMP8 | |
| SCHEMBL6954462 | 0.75 | MMP3 (0.56) | MMP13MMP3MMP1MMP2MMP8 | |
| SCHEMBL6946816 | 0.70 | MMP13 (0.40) | MMP13MMP3MMP1MMP2MMP8 | |
| SCHEMBL7077674 | 0.69 | MMP13 (0.44) | MMP13MMP3MMP1MMP2MMP8 | |
| SCHEMBL6952255 | 0.69 | MMP2 (0.41) | MMP13MMP3MMP1MMP2MMP9 | |
| SCHEMBL6949235 | 0.69 | MMP2 (0.43) | MMP13MMP3MMP1MMP2MMP8 | |
| SCHEMBL6943088 | 0.69 | MMP2 (0.49) | MMP13MMP3MMP1MMP2MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030836-B1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LTD (GB) | 2003-01-29 | — | — | EP | claimed |