Ethylene

Ethylene

SCHEMBL6948006

C=C.CCOC(C)OCC.O=C1CCC2CCC1N2Cc1ccccc1

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 4/20 0.43
TACR1 P25103 1/20 0.34
CHRNB2 P17787 1/20 0.34
CHRNA7 P36544 1/20 0.34
CHRNA4 P43681 1/20 0.34
MEN1 O00255 1/20 0.34
ALDH1A1 P00352 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C19 P33261 1/20 0.34
KMT2A Q03164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6949097 0.84 SIGMAR1 (0.49) SIGMAR1CHRNB2CHRNA7CHRNA4ALDH1A1
Ethylene SCHEMBL6945882 0.77 HTR2A (0.35) SIGMAR1ALDH1A1CYP2D6CYP2C19KMT2A
SCHEMBL21308106 0.76 SIGMAR1 (0.44) SIGMAR1CHRNB2CHRNA7CHRNA4ALDH1A1
SCHEMBL31045767 0.76 SIGMAR1 (0.44) SIGMAR1CHRNB2CHRNA7CHRNA4ALDH1A1
SCHEMBL17595348 0.76 SIGMAR1 (0.47) SIGMAR1ALDH1A1KMT2A
Ethylene SCHEMBL6675160 0.67 LMNA (0.44)
SCHEMBL20483452 0.66 CHRM2 (0.64) SIGMAR1CHRNB2CHRNA7CHRNA4MEN1
SCHEMBL1631416 0.65 KMT2A (0.46) SIGMAR1ALDH1A1KMT2A
SCHEMBL11776863 0.64 ALDH1A1 (0.47) MEN1ALDH1A1KMT2A
Phenylacetaldehyde SCHEMBL1412189 0.64 LMNA (0.41) SIGMAR1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1244450-A4 8-AZA-BICYCLO[3.2.1]OCTANE NMDA/NR2B ANTAGONISTS MERCK & CO INC (US) 2003-03-19 EP disclosed
EP-1244450-A1 8-AZA-BICYCLO[3.2.1]OCTANE NMDA/NR2B ANTAGONISTS Merck & Co., Inc. (US) 2002-10-02 EP disclosed
US-6432976-B1 ANALGESICS; SIDE EFFECT REDUCTION MERCK & CO., INC. 2002-08-13 US disclosed
WO-2001032179-A1 8-AZA-BICYCLO[3.2.1]OCTANE NMDA/NR2B ANTAGONISTS MERCK & CO., INC. (US) 2001-05-10 WO disclosed