Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | CTSC | P53634 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984895 | 0.85 | CTSC (0.33) | TGFBR1P2RX3CTSCMGLL | |
| SCHEMBL6942160 | 0.84 | ADAM17 (0.37) | CTSC | |
| SCHEMBL6946755 | 0.81 | TGFBR1 (0.32) | TGFBR1P2RX3 | |
| SCHEMBL6942423 | 0.81 | TGFBR1 (0.33) | TGFBR1P2RX3 | |
| SCHEMBL6947105 | 0.81 | P2RX3 (0.34) | TGFBR1P2RX3 | |
| SCHEMBL6945779 | 0.81 | TGFBR1 (0.33) | TGFBR1P2RX3 | |
| SCHEMBL7928806 | 0.80 | P2RX3 (0.34) | TGFBR1P2RX3CTSCMGLL | |
| SCHEMBL6943948 | 0.80 | TGFBR1 (0.33) | TGFBR1 | |
| SCHEMBL7938335 | 0.80 | TGFBR1 (0.33) | TGFBR1P2RX3 | |
| SCHEMBL6944379 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |