Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 4/20 | 0.55 |
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.33 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.33 |
| ▸ | AKT1 | P31749 | 2/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CTSC | P53634 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6948137 | 1.00 | ADAM17 (0.55) | ADAM17HTR2AGRIK1GRIK2AKT1 | |
| SCHEMBL6944663 | 0.93 | ADAM17 (0.56) | ADAM17HTR2AGRIK1GRIK2CTSC | |
| SCHEMBL6986274 | 0.91 | ADAM17 (0.52) | ADAM17GRIK1GRIK2ALDH1A1 | |
| SCHEMBL7935009 | 0.86 | ADAM17 (0.76) | ADAM17HTR2AGRIK1GRIK2 | |
| SCHEMBL6942567 | 0.86 | ADAM17 (0.73) | ADAM17 | |
| SCHEMBL8097968 | 0.86 | ADAM17 (0.73) | ADAM17 | |
| SCHEMBL6942575 | 0.86 | ADAM17 (0.73) | ADAM17 | |
| SCHEMBL6942562 | 0.86 | ADAM17 (0.73) | ADAM17 | |
| SCHEMBL6220496 | 0.84 | ADAM17 (0.48) | ADAM17HTR2AGRIK1GRIK2ALDH1A1 | |
| SCHEMBL6220493 | 0.84 | ADAM17 (0.48) | ADAM17HTR2AGRIK1GRIK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |