Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 3/20 | 0.76 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.36 |
| ▸ | NPR3 | P17342 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 2/20 | 0.33 |
| ▸ | MMP13 | P45452 | 2/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.32 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4481744 | 0.87 | ADAM17 (1.00) | ADAM17MMP1MMP13MMP9 | |
| SCHEMBL6813844 | 0.87 | ADAM17 (1.00) | ADAM17MMP1MMP13MMP9 | |
| SCHEMBL3500092 | 0.87 | ADAM17 (1.00) | ADAM17MMP1MMP13MMP9 | |
| SCHEMBL6813847 | 0.87 | ADAM17 (1.00) | ADAM17MMP1MMP13MMP9 | |
| SCHEMBL13274076 | 0.87 | ADAM17 (1.00) | ADAM17MMP1MMP13MMP9 | |
| SCHEMBL6944663 | 0.86 | ADAM17 (0.56) | ADAM17MMP1GRIK1GRIK2HTR2A | |
| SCHEMBL6948137 | 0.86 | ADAM17 (0.55) | ADAM17GRIK1GRIK2HTR2A | |
| SCHEMBL6948147 | 0.86 | ADAM17 (0.55) | ADAM17GRIK1GRIK2HTR2A | |
| SCHEMBL6945362 | 0.84 | ADAM17 (0.54) | ADAM17PSMB5NPR3MMP1MMP13 | |
| SCHEMBL6986274 | 0.83 | ADAM17 (0.52) | ADAM17RENGRIK1GRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |