Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 4/20 | 0.52 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
| ▸ | REN | P00797 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 6/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | ATM | Q13315 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.32 |
| ▸ | POLB | P06746 | 4/20 | 0.32 |
| ▸ | RECQL | P46063 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.31 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6948147 | 0.91 | ADAM17 (0.55) | ADAM17ALDH1A1GRIK1GRIK2 | |
| SCHEMBL6948137 | 0.91 | ADAM17 (0.55) | ADAM17ALDH1A1GRIK1GRIK2 | |
| SCHEMBL6944663 | 0.89 | ADAM17 (0.56) | ADAM17MAPTMAPK1KMT2AATM | |
| SCHEMBL7931029 | 0.89 | ADAM17 (0.57) | ADAM17GRIK1GRIK2 | |
| SCHEMBL6943851 | 0.88 | ADAM17 (0.67) | ADAM17 | |
| SCHEMBL7935009 | 0.83 | ADAM17 (0.76) | ADAM17RENGRIK1GRIK2 | |
| SCHEMBL6981638 | 0.81 | ADAM17 (0.46) | ADAM17AAK1RENGRIK1GRIK2 | |
| SCHEMBL6220493 | 0.81 | ADAM17 (0.48) | ADAM17RENMAPTMAPK1KMT2A | |
| SCHEMBL6220496 | 0.81 | ADAM17 (0.48) | ADAM17RENMAPTMAPK1KMT2A | |
| SCHEMBL6220502 | 0.81 | ADAM17 (0.48) | ADAM17RENMAPTMAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| EP-1133471-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-09-17 | — | — | EP | disclosed |
| US-6265446-B1 | ANTIINFLAMMATORY AGENTS; AUTOIMMUNE DISEASES | HOFFMANN-LA ROCHE INC.. | 2001-07-24 | — | — | US | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |