Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 1/20 | 0.43 |
| ▸ | FAP | Q12884 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29091690 | 0.83 | LMNA (0.46) | CYP1A2CYP2C9SMN1; SMN2KDM4ETDP1 | |
| SCHEMBL21848509 | 0.83 | LMNA (0.46) | CYP1A2CYP2C9SMN1; SMN2KDM4ETDP1 | |
| SCHEMBL10335429 | 0.83 | CTSL (0.51) | — | |
| SCHEMBL3497149 | 0.81 | MGLL (0.31) | MGLL | |
| SCHEMBL8644559 | 0.81 | MGLL (0.31) | MGLL | |
| SCHEMBL8867086 | 0.81 | MGLL (0.31) | MGLL | |
| SCHEMBL16865569 | 0.79 | CTSL (0.41) | ALDH1A1MGLLHPGDLMNAACE | |
| SCHEMBL7202631 | 0.79 | CTSL (0.58) | GAAALDH1A1RAB9ALMNAACE | |
| SCHEMBL14366653 | 0.79 | CTSK (0.50) | PREPCYP1A2CYP2D6CYP2C9RAB9A | |
| SCHEMBL10345811 | 0.79 | CTSK (0.50) | PREPCYP1A2CYP2D6CYP2C9RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192128-A4 | THIOL DERIVATIVE, METALLO-BETA-LACTAMASE INHIBITORS | MERCK & CO INC (US) | 2003-07-02 | — | — | EP | disclosed |
| EP-1192128-A1 | THIOL DERIVATIVE, METALLO-BETA-LACTAMASE INHIBITORS | Merck & Co., Inc. (US) | 2002-04-03 | — | — | EP | disclosed |
| US-20020019543-A1 | Thiol derivative, metallo-beta-lactamase inhibitors | BALKOVEC JAMES M (US) | 2002-02-14 | — | — | US | disclosed |
| WO-2000076962-A1 | THIOL DERIVATIVE, METALLO-BETA-LACTAMASE INHIBITORS | MERCK & CO., INC. (US) | 2000-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020019543-A1 | Thiol derivative, metallo-beta-lactamase inhibitors | CBR1, LBR, CBR3 | PREP 1851/4885FAP 3665/4885CYP1A2 318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.