Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.40 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.39 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6946473 | 0.87 | NPC1 (0.50) | PARP1NPC1RAB9ABRD4CREBBP | |
| SCHEMBL6948942 | 0.85 | BRD4 (0.50) | PARP1NPC1RAB9ABRD4CREBBP | |
| SCHEMBL6949839 | 0.84 | CHEK1 (0.50) | PARP1NPC1RAB9ABRD4CREBBP | |
| SCHEMBL6948426 | 0.82 | NPC1 (0.45) | NPC1RAB9AHDAC6NTRK1GAA | |
| SCHEMBL6945364 | 0.82 | RAB9A (0.52) | PARP1NPC1RAB9ABRD4CREBBP | |
| SCHEMBL6948954 | 0.81 | NPC1 (0.55) | PARP1NPC1RAB9AHDAC6RNASEH1 | |
| SCHEMBL6946441 | 0.81 | PARP1 (0.48) | PARP1NPC1RAB9ABRD4CREBBP | |
| SCHEMBL29412049 | 0.79 | PARP1 (0.60) | PARP1NPC1RAB9A | |
| SCHEMBL6942886 | 0.79 | PARP1 (0.48) | PARP1NPC1RAB9ABRD4CREBBP | |
| SCHEMBL6943109 | 0.79 | RAB9A (0.47) | PARP1NPC1RAB9ABRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0936218-B1 | BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARM CO LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-6387938-B1 | Benzimidazole derivatives | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-05-14 | — | — | US | disclosed |
| EP-0936218-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1999-08-18 | — | — | EP | disclosed |