Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 8/20 | 0.40 |
| ▸ | TDO2 | P48775 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5275526 | 0.84 | MAPT (0.51) | MAPTALDH1A1L3MBTL1IDO1TDO2 | |
| SCHEMBL31181916 | 0.81 | ALDH1A1 (0.42) | MAPTALDH1A1L3MBTL1IDO1TDO2 | |
| SCHEMBL6952027 | 0.80 | POLB (0.50) | MAPTALDH1A1L3MBTL1IDO1TDO2 | |
| SCHEMBL16111315 | 0.77 | IDO1 (0.44) | MAPTALDH1A1L3MBTL1IDO1TDO2 | |
| SCHEMBL7072166 | 0.75 | IDO1 (0.49) | MAPTALDH1A1L3MBTL1IDO1TDO2 | |
| SCHEMBL10594322 | 0.73 | MAPT (0.51) | MAPTALDH1A1L3MBTL1IDO1TDO2 | |
| SCHEMBL6374610 | 0.71 | RET (0.39) | ALDH1A1KDM4E | |
| SCHEMBL7694802 | 0.71 | MAPT (0.43) | MAPTALDH1A1L3MBTL1IDO1TDO2 | |
| SCHEMBL3948947 | 0.70 | CES1 (0.30) | — | |
| SCHEMBL17506915 | 0.70 | IDO1 (0.40) | MAPTALDH1A1L3MBTL1IDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358180-A2 | NAPHTHOSTYRIL DERIVATIVES AND THEIR USE AS INHIBITORS OF CYCLIN-DEPENDENT KINASES | F. Hoffmann-La Roche AG (CH) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002059109-A2 | NAPHTHOSTYRIL DERIVATIVES AND THEIR USE AS INHIBITORS OF CYCLIN- DEPENDENT KINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-01 | — | — | WO | disclosed |