Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | HTR1A | P08908 | 6/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | HTR1D | P28221 | 2/20 | 0.57 |
| ▸ | HTR1B | P28222 | 2/20 | 0.57 |
| ▸ | HTR2C | P28335 | 2/20 | 0.57 |
| ▸ | HTR7 | P34969 | 2/20 | 0.57 |
| ▸ | HTR6 | P50406 | 2/20 | 0.57 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11536860 | 0.85 | HTR2A (0.68) | HTR2AMAPTL3MBTL1ALDH1A1HTR1A | |
| SCHEMBL10256766 | 0.84 | HTR2A (0.64) | HTR2AMAPTL3MBTL1ALDH1A1HTR1A | |
| SCHEMBL2823989 | 0.82 | TRPM8 (0.62) | MAPTHTR1AMEN1KMT2AHTR1D | |
| SCHEMBL17525726 | 0.81 | GAA (0.66) | HTR2AMAPTALDH1A1HTR1AMEN1 | |
| SCHEMBL17525734 | 0.81 | MPO (0.64) | HTR2AHTR1AKMT2ATRPM8GPR84 | |
| SCHEMBL17525691 | 0.81 | SLC6A4 (0.49) | HTR2AMAPTL3MBTL1ALDH1A1HTR1A | |
| SCHEMBL8229566 | 0.81 | MAPT (0.87) | HTR2AMAPTL3MBTL1ALDH1A1HTR1A | |
| SCHEMBL24723815 | 0.80 | HTR2A (0.97) | HTR2AMAPTHTR1ACYP2D6CYP1A2 | |
| SCHEMBL29633130 | 0.80 | HTR2A (0.97) | HTR2AMAPTHTR1ACYP2D6CYP1A2 | |
| SCHEMBL25249411 | 0.80 | HTR2A (1.00) | HTR2AMAPTHTR1ACYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0851855-B9 | ACYLATED DERIVATIVES OF MELATONIN AND ITS ANALOGUES, USEFUL AS MEDICAMENTS | MACEF (FR) | 2003-05-21 | — | — | EP | claimed |
| EP-0851855-B1 | ACYLATED DERIVATIVES OF MELATONIN AND ITS ANALOGUES, USEFUL AS MEDICAMENTS | MACEF (FR) | 2002-06-05 | — | — | EP | claimed |
| EP-0851855-A1 | ACYLATED DERIVATIVES OF MELATONIN AND ITS ANALOGUES, USEFUL AS MEDICAMENTS | CEMAF (FR) | 1998-07-08 | — | — | EP | claimed |
| WO-1997006140-A1 | ACYLATED DERIVATIVES OF MELATONIN AND ITS ANALOGUES, USEFUL AS MEDICAMENTS | CEMAF (FR) | 1997-02-20 | — | — | WO | claimed |
| EP-0851855-B9 | ACYLATED DERIVATIVES OF MELATONIN AND ITS ANALOGUES, USEFUL AS MEDICAMENTS | MACEF (FR) | 2003-05-21 | — | — | EP | disclosed |
| EP-0851855-B1 | ACYLATED DERIVATIVES OF MELATONIN AND ITS ANALOGUES, USEFUL AS MEDICAMENTS | MACEF (FR) | 2002-06-05 | — | — | EP | disclosed |
| US-6140372-A | N-(2-(2-ACETYL-7-METHOXYNAPHTH-1-YL)ETHYL)ACETAMIDE; SEDATIVES; MELATONIN DISORDERS; DRUGS; COSMETICS; ANTIDEPRESSANTS; PSYCHIATRIC DISORDERS, E.G., STRESS, ANXIOLYTIC AGENTS, INSOMNIA, SCHIZOPHRENIA, PSYCHOSIS | CEMAF AND LABORATORIES BESINS ISOVESCO S.A. (FR) | 2000-10-31 | — | — | US | disclosed |
| US-6004991-A | COMPOUNDS FOR COSMETICS WITH ENANTIOMORPHS | CEMAF AND LABORATOIRES BESINS ISCOVESCO S.A. (FR) | 1999-12-21 | — | — | US | disclosed |
| EP-0851855-A1 | ACYLATED DERIVATIVES OF MELATONIN AND ITS ANALOGUES, USEFUL AS MEDICAMENTS | CEMAF (FR) | 1998-07-08 | — | — | EP | disclosed |
| WO-1997006140-A1 | ACYLATED DERIVATIVES OF MELATONIN AND ITS ANALOGUES, USEFUL AS MEDICAMENTS | CEMAF (FR) | 1997-02-20 | — | — | WO | disclosed |