Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 10/20 | 0.49 |
| ▸ | MMP2 | P08253 | 10/20 | 0.49 |
| ▸ | MMP9 | P14780 | 10/20 | 0.49 |
| ▸ | MMP13 | P45452 | 9/20 | 0.49 |
| ▸ | MMP1 | P03956 | 9/20 | 0.38 |
| ▸ | MMP8 | P22894 | 8/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.37 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | MMP7 | P09237 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6952255 | 0.92 | MMP2 (0.41) | MMP3MMP2MMP9MMP13MMP1 | |
| SCHEMBL6947014 | 0.88 | MMP2 (0.49) | MMP3MMP2MMP9MMP13MMP1 | |
| SCHEMBL6954462 | 0.86 | MMP3 (0.56) | MMP3MMP2MMP9MMP13MMP1 | |
| SCHEMBL6948795 | 0.79 | KMT2A (0.40) | MMP3MMP2MMP9MMP13MMP1 | |
| SCHEMBL6948783 | 0.79 | MMP13 (0.47) | MMP3MMP2MMP9MMP13MMP1 | |
| SCHEMBL6943088 | 0.78 | MMP2 (0.49) | MMP3MMP2MMP9MMP13MMP1 | |
| SCHEMBL6948525 | 0.78 | PLA2G7 (0.54) | MMP3MMP2MMP9MMP13MMP1 | |
| SCHEMBL6952757 | 0.76 | MMP3 (0.48) | MMP3MMP2MMP9MMP13MMP1 | |
| SCHEMBL6949235 | 0.72 | MMP2 (0.43) | MMP3MMP2MMP9MMP13MMP1 | |
| SCHEMBL6945478 | 0.72 | MMP2 (0.42) | MMP3MMP2MMP9MMP13MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030836-B1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LTD (GB) | 2003-01-29 | — | — | EP | claimed |