Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 13/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947113 | 0.94 | ALOX15 (0.53) | ALOX15ALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL6947587 | 0.91 | ALOX15 (0.54) | ALOX15ALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL7505803 | 0.88 | KDM4E (0.47) | ALOX15ALDH1A1MEN1KMT2ATP53 | |
| SCHEMBL6953897 | 0.87 | ENPP2 (0.44) | MEN1KMT2AKDM4ELMNAMAPT | |
| SCHEMBL7507549 | 0.87 | HPGD (0.47) | ALOX15ALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL7498695 | 0.86 | KDM4E (0.44) | ALOX15MEN1KMT2ATP53KDM4E | |
| SCHEMBL6954781 | 0.85 | KCNK3 (0.42) | ALOX15MEN1KMT2ATP53KDM4E | |
| SCHEMBL7505832 | 0.85 | KDM4E (0.49) | ALOX15ALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL7506991 | 0.84 | ALOX15 (0.44) | ALOX15ALDH1A1HSD17B10TP53KDM4E | |
| SCHEMBL6949310 | 0.83 | KCNK3 (0.40) | ALOX15MEN1KMT2ATP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0985666-B1 | Substituted indole compounds as COX-2 inhibitors | PFIZER (US) | 2003-11-05 | — | — | EP | claimed |
| US-6277878-B1 | ANTIINFLAMMATORY AGENTS; ANALGESICS | PFIZER INC | 2001-08-21 | — | — | US | claimed |
| EP-0985666-A1 | Substituted indole compounds as COX-2 inhibitors | PFIZER INC. (US) | 2000-03-15 | — | — | EP | claimed |
| EP-0985666-B1 | Substituted indole compounds as COX-2 inhibitors | PFIZER (US) | 2003-11-05 | — | — | EP | disclosed |
| US-6277878-B1 | ANTIINFLAMMATORY AGENTS; ANALGESICS | PFIZER INC | 2001-08-21 | — | — | US | disclosed |
| EP-0985666-A1 | Substituted indole compounds as COX-2 inhibitors | PFIZER INC. (US) | 2000-03-15 | — | — | EP | disclosed |