Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 14/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6949026 | 0.94 | ALOX15 (0.52) | ALOX15ALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL6947587 | 0.93 | ALOX15 (0.54) | ALOX15ALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL7502054 | 0.86 | KDM4E (0.46) | ALOX15ALDH1A1TP53KDM4EHPGD | |
| SCHEMBL6954951 | 0.85 | ENPP2 (0.44) | ALOX15 | |
| SCHEMBL7503090 | 0.85 | GSK3B (0.49) | ALOX15ALDH1A1HSD17B10TP53KDM4E | |
| SCHEMBL7504271 | 0.84 | KDM4E (0.47) | ALOX15MEN1KMT2ATP53KDM4E | |
| SCHEMBL7501433 | 0.83 | KDM4E (0.49) | ALOX15ALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL7514680 | 0.82 | GSK3B (0.44) | ALOX15ALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL6954922 | 0.81 | PKM (0.41) | ALOX15ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL6946118 | 0.81 | ALDH1A1 (0.54) | ALOX15ALDH1A1HSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0985666-B1 | Substituted indole compounds as COX-2 inhibitors | PFIZER (US) | 2003-11-05 | — | — | EP | claimed |
| US-6277878-B1 | ANTIINFLAMMATORY AGENTS; ANALGESICS | PFIZER INC | 2001-08-21 | — | — | US | claimed |
| EP-0985666-A1 | Substituted indole compounds as COX-2 inhibitors | PFIZER INC. (US) | 2000-03-15 | — | — | EP | claimed |
| EP-0985666-B1 | Substituted indole compounds as COX-2 inhibitors | PFIZER (US) | 2003-11-05 | — | — | EP | disclosed |
| US-6277878-B1 | ANTIINFLAMMATORY AGENTS; ANALGESICS | PFIZER INC | 2001-08-21 | — | — | US | disclosed |
| EP-0985666-A1 | Substituted indole compounds as COX-2 inhibitors | PFIZER INC. (US) | 2000-03-15 | — | — | EP | disclosed |