Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | EIF4EBP1 | Q13541 | 7/20 | 0.35 |
| ▸ | CYP2C8 | P10632 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.32 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6949037 | 1.00 | KDM4E (0.35) | KDM4EKMT2AMEN1POLBEIF4EBP1 | |
| SCHEMBL8783752 | 0.93 | PDE7A (0.34) | KDM4EKMT2AMEN1POLBEIF4EBP1 | |
| SCHEMBL8783754 | 0.93 | PDE7A (0.34) | KDM4EKMT2AMEN1POLBEIF4EBP1 | |
| SCHEMBL6950342 | 0.84 | KMT2A (0.37) | KDM4EKMT2AMEN1POLBEIF4EBP1 | |
| SCHEMBL9206247 | 0.82 | KMT2A (0.34) | KDM4EKMT2AMEN1POLBEIF4EBP1 | |
| SCHEMBL8784811 | 0.81 | P2RX3 (0.36) | KDM4EKMT2AMEN1POLBEIF4EBP1 | |
| SCHEMBL8784802 | 0.81 | P2RX3 (0.36) | KDM4EKMT2AMEN1POLBEIF4EBP1 | |
| SCHEMBL8784252 | 0.81 | EIF4EBP1 (0.34) | KDM4EKMT2AMEN1POLBEIF4EBP1 | |
| SCHEMBL9206253 | 0.81 | EIF4EBP1 (0.34) | KDM4EKMT2AMEN1POLBEIF4EBP1 | |
| SCHEMBL8784371 | 0.80 | EIF4EBP1 (0.31) | KDM4EKMT2AMEN1POLBEIF4EBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0758328-B1 | ANTI-CANCER COMPOUNDS CONTAINING CYCLOPENTAQUINAZOLINE RING | BTG INT LTD (GB) | 2003-07-16 | — | — | EP | disclosed |
| EP-0667864-B1 | TRICYCLIC COMPOUNDS WITH PHARMACEUTICAL ACTIVITY | ZENECA LTD (GB) | 1997-09-24 | — | — | EP | disclosed |