Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 2/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | EIF4EBP1 | Q13541 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8784811 | 1.00 | P2RX3 (0.36) | P2RX3AGTR1AGTR2KDM4ENPC1 | |
| SCHEMBL6949348 | 0.87 | KMT2A (0.36) | KDM4ENPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8784371 | 0.86 | EIF4EBP1 (0.31) | AGTR1AGTR2KDM4EKMT2AMEN1 | |
| SCHEMBL6949037 | 0.81 | KDM4E (0.35) | KDM4ENPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6949031 | 0.81 | KDM4E (0.35) | KDM4ENPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8783754 | 0.81 | PDE7A (0.34) | KDM4ENPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8783752 | 0.81 | PDE7A (0.34) | KDM4ENPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8784252 | 0.79 | EIF4EBP1 (0.34) | KDM4EKMT2AMEN1LMNAPOLB | |
| SCHEMBL6950342 | 0.79 | KMT2A (0.37) | KDM4ESMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL8783227 | 0.78 | CD38 (0.40) | KDM4ENPC1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0758328-A1 | ANTI-CANCER COMPOUNDS CONTAINING CYCLOPENTAQUINAZOLINE RING | BTG INTERNATIONAL LIMITED (GB) | 1997-02-19 | — | — | EP | disclosed |
| WO-1995030673-A1 | ANTI-CANCER COMPOUNDS CONTAINING CYCLOPENTAQUINAZOLINE RING | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1995-11-16 | — | — | WO | disclosed |