Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 4/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8091860 | 0.89 | LMNA (0.41) | CYP19A1HTR1ASIGMAR1GBA1ADRA1D | |
| Fumaric Acid SCHEMBL8091873 | 0.89 | LMNA (0.41) | CYP19A1HTR1ASIGMAR1GBA1ADRA1D | |
| SCHEMBL8091868 | 0.70 | CYP19A1 (0.37) | CYP19A1HTR1AGBA1ADRA1DADRA1A | |
| SCHEMBL599314 | 0.68 | CYP19A1 (0.54) | CYP19A1HTR1ASIGMAR1OPRM1OPRL1 | |
| SCHEMBL6959621 | 0.67 | ADRA2A (0.45) | CYP19A1HTR1AADRA2ACYP11B2 | |
| SCHEMBL6950361 | 0.66 | CYP19A1 (0.46) | CYP19A1HTR1ASIGMAR1OPRM1OPRL1 | |
| SCHEMBL9139949 | 0.65 | HTR1A (0.53) | CYP19A1HTR1ASIGMAR1OPRM1OPRL1 | |
| SCHEMBL1689733 | 0.65 | PLAU (0.55) | CYP19A1HTR1ASIGMAR1OPRM1OPRL1 | |
| SCHEMBL9935276 | 0.65 | CYP19A1 (0.54) | CYP19A1HTR1ASIGMAR1OPRM1OPRL1 | |
| SCHEMBL15701675 | 0.65 | CYP19A1 (0.54) | CYP19A1HTR1ASIGMAR1OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1010693-B1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-09-24 | — | — | EP | disclosed |
| EP-1010693-A1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2000-06-21 | — | — | EP | disclosed |