Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 3/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6958891 | 1.00 | ADRA2A (0.56) | ADRA2AHTR1ADRD2HTR2AHTR2C | |
| SCHEMBL6949759 | 1.00 | ADRA2A (0.56) | ADRA2AHTR1ADRD2HTR2AHTR2C | |
| Fumaric Acid SCHEMBL8091878 | 0.89 | ADRA2A (0.46) | ADRA2AHTR1ADRD2HTR2AHTR2C | |
| Fumaric Acid SCHEMBL8092398 | 0.89 | ADRA2A (0.46) | ADRA2AHTR1ADRD2HTR2AHTR2C | |
| Fumaric Acid SCHEMBL8091870 | 0.89 | ADRA2A (0.46) | ADRA2AHTR1ADRD2HTR2AHTR2C | |
| Fumaric Acid SCHEMBL8092403 | 0.89 | ADRA2A (0.46) | ADRA2AHTR1ADRD2HTR2AHTR2C | |
| Fumaric Acid SCHEMBL8085005 | 0.89 | ADRA2A (0.46) | ADRA2AHTR1ADRD2HTR2AHTR2C | |
| Fumaric Acid SCHEMBL8085007 | 0.89 | ADRA2A (0.46) | ADRA2AHTR1ADRD2HTR2AHTR2C | |
| SCHEMBL6955357 | 0.87 | ACHE (0.47) | ADRA2AHTR1AHTR2AHTR7DRD3 | |
| SCHEMBL6960180 | 0.81 | ADRA2A (0.37) | ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1010693-B1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-09-24 | — | — | EP | disclosed |
| EP-1010693-A1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2000-06-21 | — | — | EP | disclosed |