Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.32 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.32 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.32 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8092403 | 1.00 | ADRA2A (0.46) | ADRA2AMITFHSP90AA1RAB9ALMNA | |
| Fumaric Acid SCHEMBL8085007 | 1.00 | ADRA2A (0.46) | ADRA2AMITFHSP90AA1RAB9ALMNA | |
| Fumaric Acid SCHEMBL8091878 | 1.00 | ADRA2A (0.46) | ADRA2AMITFHSP90AA1RAB9ALMNA | |
| Fumaric Acid SCHEMBL8085005 | 1.00 | ADRA2A (0.46) | ADRA2AMITFHSP90AA1RAB9ALMNA | |
| Fumaric Acid SCHEMBL8091870 | 1.00 | ADRA2A (0.46) | ADRA2AMITFHSP90AA1RAB9ALMNA | |
| Fumaric Acid SCHEMBL8097779 | 0.90 | ACHE (0.39) | ADRA2ALMNABLMHTR1AHTR2A | |
| Fumaric Acid SCHEMBL8097770 | 0.90 | ACHE (0.39) | ADRA2ALMNABLMHTR1AHTR2A | |
| SCHEMBL6949362 | 0.89 | ADRA2A (0.56) | ADRA2AHTR1ADRD2HTR2AHTR2C | |
| SCHEMBL6949759 | 0.89 | ADRA2A (0.56) | ADRA2AHTR1ADRD2HTR2AHTR2C | |
| SCHEMBL6958891 | 0.89 | ADRA2A (0.56) | ADRA2AHTR1ADRD2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127396-A | Imidazoline compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |