Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.77 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | CNR1 | P21554 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | USP5 | P45974 | 2/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | F10 | P00742 | 1/20 | 0.49 |
| ▸ | LSS | P48449 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7549029 | 0.82 | L3MBTL1 (0.67) | TP53LMNAPOLBL3MBTL1CNR1 | |
| SCHEMBL1946614 | 0.79 | L3MBTL1 (0.75) | TP53LMNAPOLBL3MBTL1CNR1 | |
| Hydrochloric Acid SCHEMBL6196960 | 0.76 | F10 (0.75) | TP53LMNACNR1NPSR1F10 | |
| Hydrochloric Acid SCHEMBL6196964 | 0.76 | F10 (0.75) | TP53LMNACNR1NPSR1F10 | |
| SCHEMBL6945244 | 0.75 | LSS (0.70) | TP53USP5LSS | |
| SCHEMBL20772177 | 0.75 | TP53 (0.75) | TP53LMNANPSR1USP5HSD11B1 | |
| SCHEMBL5915276 | 0.74 | TP53 (0.74) | TP53LMNAL3MBTL1USP5 | |
| SCHEMBL29505151 | 0.74 | TP53 (0.69) | TP53LMNAL3MBTL1CNR1NPSR1 | |
| SCHEMBL14456956 | 0.73 | CNR1 (0.69) | LMNAPOLBCNR1NPSR1F10 | |
| SCHEMBL4562521 | 0.73 | KDM4E (0.45) | TP53LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966462-B1 | HETEROCYCLIC COMPOUNDS USEFUL AS OXIDO-SQUALENE CYCLASE INHIBITORS | ASTRAZENECA AB (SE) | 2003-06-11 | — | — | EP | disclosed |
| US-6391880-B1 | ANTICHOLESTEROL AGENTS | ZENECA LIMITED (GB) | 2002-05-21 | — | — | US | disclosed |
| EP-0966462-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS OXIDO-SQUALENE CYCLASE INHIBITORS | ZENECA LIMITED (GB) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998035959-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS OXIDO-SQUALENE CYCLASE INHIBITORS | ZENECA LIMITED (GB) | 1998-08-20 | — | — | WO | disclosed |