Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.66 |
| ▸ | F10 | P00742 | 1/20 | 0.60 |
| ▸ | LSS | P48449 | 3/20 | 0.57 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.55 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.55 |
| ▸ | CNR1 | P21554 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5250449 | 0.91 | HSD11B1 (0.64) | L3MBTL1LMNAF10LSSHSD11B1 | |
| SCHEMBL6180621 | 0.89 | F10 (0.76) | L3MBTL1LMNAPOLBF10CHRM1 | |
| SCHEMBL5462593 | 0.88 | PKM (0.67) | L3MBTL1LMNALSSAKR1C3CHRM1 | |
| SCHEMBL7446074 | 0.88 | LSS (0.73) | L3MBTL1LMNAPOLBF10LSS | |
| SCHEMBL7442116 | 0.85 | L3MBTL1 (0.58) | L3MBTL1LSSAKR1C3CHRM1HSD11B1 | |
| SCHEMBL1387325 | 0.82 | F10 (0.77) | F10LSSCHRM1CNR1HTT | |
| SCHEMBL6949494 | 0.82 | TP53 (0.77) | L3MBTL1LMNAPOLBF10LSS | |
| SCHEMBL1946614 | 0.82 | L3MBTL1 (0.75) | L3MBTL1LMNAPOLBAKR1C3CNR1 | |
| SCHEMBL5489738 | 0.81 | ATM (0.71) | L3MBTL1LMNAF10LSSCHRM1 | |
| SCHEMBL5250380 | 0.81 | HSD11B1 (0.78) | L3MBTL1LMNALSSHSD11B1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6440972-B1 | Heterocyclic compounds useful as oxido-squalene cyclase inhibitors | ZENECA LIMITED (GB) | 2002-08-27 | — | — | US | disclosed |
| EP-0966460-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS OXIDO-SQUALENE CYCLASE INHIBITORS | ZENECA LIMITED (GB) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998035956-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS OXIDO-SQUALENE CYCLASE INHIBITORS | ZENECA LIMITED (US) | 1998-08-20 | — | — | WO | disclosed |