Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | CASP3 | P42574 | 1/20 | 0.55 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.55 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.55 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9787068 | 0.80 | LMNA (0.80) | L3MBTL1LMNAMAPK1CASP3SENP7 | |
| SCHEMBL6949804 | 0.76 | PSMB5 (0.45) | L3MBTL1LMNAMAPK1CASP3SENP7 | |
| SCHEMBL437173 | 0.74 | LMNA (0.49) | L3MBTL1LMNAMAPK1CASP3SENP7 | |
| SCHEMBL1601388 | 0.73 | LTA4H (0.55) | LMNALTA4HNPC1KMT2AMEN1 | |
| SCHEMBL22668512 | 0.72 | SMN1; SMN2 (0.50) | L3MBTL1LMNAMAPK1CASP3SENP7 | |
| SCHEMBL6818113 | 0.72 | KMT2A (0.53) | LMNACASP3SENP7SENP6NPC1 | |
| SCHEMBL9787330 | 0.71 | LMNA (0.74) | L3MBTL1LMNAMAPK1CASP3SENP7 | |
| SCHEMBL411054 | 0.70 | L3MBTL1 (0.49) | L3MBTL1LMNAMAPK1HSD11B1TDP1 | |
| SCHEMBL1772590 | 0.70 | LTA4H (0.51) | LMNALTA4HNPC1SMN1; SMN2RAB9A | |
| SCHEMBL6434986 | 0.69 | P4HTM (0.62) | L3MBTL1LMNATDP1PLA2G10PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082121-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2003-02-05 | — | — | EP | disclosed |
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | disclosed |
| EP-1082121-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999062520-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | disclosed |