Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 15/20 | 0.66 |
| ▸ | PTPN2 | P17706 | 5/20 | 0.53 |
| ▸ | PTPN6 | P29350 | 4/20 | 0.53 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.53 |
| ▸ | PGK1 | P00558 | 2/20 | 0.53 |
| ▸ | PGK2 | P07205 | 2/20 | 0.53 |
| ▸ | PTPRC | P08575 | 3/20 | 0.48 |
| ▸ | PTPRB | P23467 | 2/20 | 0.48 |
| ▸ | CDC25A | P30304 | 1/20 | 0.48 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7831965 | 0.83 | PTPN1 (0.75) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| Phosphonodifluoromethyl Phenylalanine SCHEMBL9545904 | 0.79 | PTPN1 (1.00) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| Phosphonodifluoromethyl Phenylalanine SCHEMBL2517439 | 0.79 | PTPN1 (1.00) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| Phosphonodifluoromethyl Phenylalanine SCHEMBL2517440 | 0.79 | PTPN1 (1.00) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL7697483 | 0.79 | PTPN1 (0.65) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL2561452 | 0.76 | CYP1A2 (0.57) | — | |
| SCHEMBL7888265 | 0.75 | PTPN1 (0.63) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL330067 | 0.74 | PTPN1 (0.70) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL27715838 | 0.74 | PTPN1 (0.78) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL3385203 | 0.73 | PTPN1 (0.66) | PTPN1PTPN2PTPN6PTPN11PGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115729-B1 | PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PTP-1B | MERCK FROSST CANADA INC (CA) | 2003-02-19 | — | — | EP | claimed |
| EP-1115729-A1 | PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PTP-1B | Merck Frosst Canada & Co. (CA) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000017211-A1 | PHOSPHONIC ACIDS DERIVATIVES AS INHIBITORS OF PTP-1B | MERCK FROSST CANADA & CO. (CA) | 2000-03-30 | — | — | WO | disclosed |