Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 14/20 | 0.65 |
| ▸ | PTPN2 | P17706 | 6/20 | 0.55 |
| ▸ | PTPN6 | P29350 | 5/20 | 0.55 |
| ▸ | PTPN11 | Q06124 | 4/20 | 0.55 |
| ▸ | PGK1 | P00558 | 2/20 | 0.55 |
| ▸ | PGK2 | P07205 | 2/20 | 0.55 |
| ▸ | PTPN5 | P54829 | 3/20 | 0.50 |
| ▸ | PTPRC | P08575 | 2/20 | 0.50 |
| ▸ | PTPRB | P23467 | 2/20 | 0.50 |
| ▸ | CDC25A | P30304 | 1/20 | 0.50 |
| ▸ | PTPRA | P18433 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2269390 | 0.80 | KIF11 (0.46) | PTPN1 | |
| SCHEMBL2269572 | 0.80 | KIF11 (0.46) | PTPN1 | |
| SCHEMBL6949847 | 0.79 | PTPN1 (0.66) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| Phosphonodifluoromethyl Phenylalanine SCHEMBL2517440 | 0.79 | PTPN1 (1.00) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| Phosphonodifluoromethyl Phenylalanine SCHEMBL2517439 | 0.79 | PTPN1 (1.00) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| Phosphonodifluoromethyl Phenylalanine SCHEMBL9545904 | 0.79 | PTPN1 (1.00) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL27715838 | 0.79 | PTPN1 (0.78) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL7831965 | 0.76 | PTPN1 (0.75) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL14679499 | 0.76 | GRB2 (0.54) | PTPN1 | |
| SCHEMBL10068446 | 0.76 | PGK1 (0.49) | PGK1PGK2PTPRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6114132-A | FOR DETERMINING THE BINDING ABILITY OF A LIGAND TO A CYSTEINE-CONTAINING WILD-TYPE TYROSINE PHOSPHATASE; MEDICAL DIAGNOSIS | MERCK FROSST CANADA & CO. (CA) | 2000-09-05 | — | — | US | claimed |
| EP-0937157-A1 | HYDROLASE BINDING ASSAY | Merck Frosst Canada & Co. (CA) | 1999-08-25 | — | — | EP | claimed |
| WO-1998020156-A1 | HYDROLASE BINDING ASSAY | MERCK FROSST CANADA & CO. (CA) | 1998-05-14 | — | — | WO | claimed |
| US-6348572-B1 | TRIPEPTIDE CONTAINING 4-PHOSPHONO(DIFLUOROMETHYL)PHENYLALANINE GROUPS; TYROSINE PHOSPHATASE AND CYSTEINE PROTEASE ASSAYS; COMPETITIVE BINDING; DIABETES, CANCER, ALZHEIMER*S DISEASE, OSTEOPOROSIS | MERCK FROSST CANADA & CO. (CA) | 2002-02-19 | — | — | US | disclosed |
| US-6114132-A | FOR DETERMINING THE BINDING ABILITY OF A LIGAND TO A CYSTEINE-CONTAINING WILD-TYPE TYROSINE PHOSPHATASE; MEDICAL DIAGNOSIS | MERCK FROSST CANADA & CO. (CA) | 2000-09-05 | — | — | US | disclosed |
| US-6066715-A | TRIPEPTIDE FOR USE IN ENZYME ANALYSIS; FOR THE TREATMENT OF ALZHEIMER'S DISEASE, OSTEOPOROSIS AND IMMUNOSUPPRESSION; ANTICARCINOGENIC AND ANTIDIABETIC AGENTS | MERCK FROSST CANADA & CO. (CA) | 2000-05-23 | — | — | US | disclosed |
| EP-0941232-A1 | LIGANDS FOR PHOSPHATASE BINDING ASSAY | MERCK FROSST CANADA INC. (CA) | 1999-09-15 | — | — | EP | disclosed |
| EP-0937157-A1 | HYDROLASE BINDING ASSAY | Merck Frosst Canada & Co. (CA) | 1999-08-25 | — | — | EP | disclosed |
| WO-1998020156-A1 | HYDROLASE BINDING ASSAY | MERCK FROSST CANADA & CO. (CA) | 1998-05-14 | — | — | WO | disclosed |
| WO-1998020024-A1 | LIGANDS FOR PHOSPHATASE BINDING ASSAY | MERCK FROSST CANADA & CO. (CA) | 1998-05-14 | — | — | WO | disclosed |