SCHEMBL6949977

SCHEMBL6949977

COc1cc(N)c(Cl)cc1C(=O)NC1CC2CN(C)CC(C1)N2C

nearest known ligand 0.84

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HTR4 Q13639 6/20 0.84
DRD2 P14416 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7292676 0.91 HTR4 (1.00) HTR4DRD2
SCHEMBL8722682 0.91 HTR4 (1.00) HTR4DRD2
SCHEMBL7292915 0.89 HTR4 (0.84) HTR4DRD2
SCHEMBL6955611 0.85 DRD2 (0.73) HTR4DRD2
SCHEMBL4895943 0.84 HTR4 (0.61) HTR4DRD2
SCHEMBL4895956 0.84 HTR4 (0.61) HTR4DRD2
SCHEMBL7337602 0.84 HTR4 (0.71) HTR4
Hydrochloric Acid SCHEMBL4887837 0.83 HTR4 (0.60) HTR4DRD2
SCHEMBL6235633 0.83 HTR4 (0.60) HTR4DRD2
Hydrochloric Acid SCHEMBL4887826 0.83 HTR4 (0.60) HTR4DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0550550-B1 3,9-DIAZABICYCLO (3.3.1) NONAN-7-YL DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM BEECHAM GROUP PLC (GB) 2003-07-16 EP claimed
EP-0550550-A1 3,9-DIAZABICYCLO (3.3.1) NONAN-7-YL DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Beecham Group p.l.c. (GB) 1993-07-14 EP claimed
WO-1992005174-A1 3,9-DIAZABICYCLO (3.3.1) NONAN-7-YL DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM BEECHAM GROUP PLC (GB) 1992-04-02 WO claimed
EP-0550550-B1 3,9-DIAZABICYCLO (3.3.1) NONAN-7-YL DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM BEECHAM GROUP PLC (GB) 2003-07-16 EP disclosed
US-5256656-A Antiserotonine agent NISSHIN FLOUR MILLING CO., LTD. (JP) 1993-10-26 US disclosed
EP-0550550-A1 3,9-DIAZABICYCLO (3.3.1) NONAN-7-YL DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Beecham Group p.l.c. (GB) 1993-07-14 EP disclosed
WO-1992005174-A1 3,9-DIAZABICYCLO (3.3.1) NONAN-7-YL DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM BEECHAM GROUP PLC (GB) 1992-04-02 WO disclosed
EP-0469449-A1 Azabicyclo derivatives NISSHIN FLOUR MILLING CO., LTD. (JP) 1992-02-05 EP disclosed