Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 5/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | BMP1 | P13497 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7829381 | 0.82 | MAPT (0.52) | KEAP1NFE2L2LMNATAS2R14MAPT | |
| SCHEMBL2109904 | 0.73 | TAS2R14 (0.68) | TAS2R14MAPT | |
| SCHEMBL9390270 | 0.72 | PKM (0.70) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL21773447 | 0.70 | BMP1 (0.59) | KEAP1NFE2L2TAS2R14BMP1 | |
| SCHEMBL28206910 | 0.69 | IDO1 (0.56) | SMN1; SMN2MAPTALDH1A1TSHR | |
| SCHEMBL5893516 | 0.68 | CYP1A1 (0.57) | SMN1; SMN2MAPTKMT2A | |
| SCHEMBL28654739 | 0.67 | IDO1 (0.58) | SMN1; SMN2MAPTALDH1A1TSHR | |
| SCHEMBL2883 | 0.67 | IDO1 (0.58) | SMN1; SMN2MAPTALDH1A1TSHR | |
| SCHEMBL2468075 | 0.67 | LMNA (0.66) | HTTLMNAL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL21646291 | 0.67 | SMN1; SMN2 (0.46) | HTTLMNATAS2R14SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115729-B1 | PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PTP-1B | MERCK FROSST CANADA INC (CA) | 2003-02-19 | — | — | EP | disclosed |
| US-6174874-B1 | ANTIDIABETIC,-CARCINOGENIC AGENTS; IMPROVING GLUCOSE TOLERANCE/INSULIN-SENSITIVITY; PREVENTING/TREATING OBESITY AND NEURODEGENERATIVE DISEASES; E.G. 1,3-BIS-((PHOSPHONODI-FLUOROMETHYL)PHENYL)-2-DICARBOXYPROPANE | MERCK FROSST CANADA & CO. (CA) | 2001-01-16 | — | — | US | disclosed |