SCHEMBL6950103

SCHEMBL6950103

CCOC(=O)C(Cc1ccc(Cl)c2occc12)C(=O)OCC

nearest known ligand 0.40

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.38
TSHR P16473 2/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2C9 P11712 1/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
MMP8 P22894 1/20 0.35
KDM4E B2RXH2 1/20 0.34
HPGD P15428 1/20 0.34
MAPT P10636 2/20 0.34
PSMB5 P28074 1/20 0.33
KMT2A Q03164 2/20 0.33
POLB P06746 1/20 0.33
HTT P42858 1/20 0.33
MEN1 O00255 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
CYP4F2 P78329 1/20 0.32
CYP4A11 Q02928 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Malonic Acid Diethyl Ester SCHEMBL8506948 0.94 ALDH1A1 (0.35) ALDH1A1TSHRCYP3A4CYP2C9SMN1; SMN2
SCHEMBL6950106 0.81 MAPT (0.34) MAPTPSMB5
SCHEMBL6956656 0.79 CYP4F2 (0.46) ALDH1A1TSHRCYP3A4CYP2C9SMN1; SMN2
SCHEMBL1339583 0.75 CYP4F2 (0.47) ALDH1A1TSHRMAPTKMT2AHTT
SCHEMBL9978726 0.72 CYP3A4 (0.61) ALDH1A1TSHRCYP3A4CYP2C9SMN1; SMN2
SCHEMBL2673394 0.71 ALDH1A1 (0.50) ALDH1A1TSHRCYP3A4CYP2C9SMN1; SMN2
SCHEMBL25347260 0.70 CYP4F2 (0.47) ALDH1A1TSHRMAPTKMT2AHTT
SCHEMBL31326222 0.70 CYP4F2 (0.47) ALDH1A1TSHRMAPTKMT2AHTT
SCHEMBL6943904 0.69 CYP3A4 (0.44) ALDH1A1TSHRCYP3A4CYP2C9SMN1; SMN2
SCHEMBL8327445 0.69 ALDH1A1 (0.48) ALDH1A1TSHRSMN1; SMN2KDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0901483-B1 BENZOFURANS AND BENZOPYRANS AS CHRONOBIOLOGICAL AGENTS GLAXO GROUP LTD (GB) 2003-07-09 EP disclosed
US-5981572-A Benzofurans and benzopyrans as chronobiological agents GLAXO WELLCOME INC. (US) 1999-11-09 US disclosed
EP-0901483-A2 BENZOFURANS AND BENZOPYRANS AS CHRONOBIOLOGICAL AGENTS GLAXO GROUP LIMITED (GB) 1999-03-17 EP disclosed
WO-1997043272-A2 BENZOFURANS AND BENZOPYRANS AS CHRONOBIOLOGICAL AGENTS GLAXO GROUP LIMITED (GB) 1997-11-20 WO disclosed