Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 1/20 | 0.49 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.49 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947145 | 0.81 | GPR119 (0.55) | SMARCA2SMARCA4PBRM1SMN1; SMN2MEN1 | |
| SCHEMBL23643942 | 0.81 | GPR119 (0.54) | SMN1; SMN2MEN1KMT2ACYP2C19LMNA | |
| SCHEMBL6976827 | 0.76 | L3MBTL1 (0.50) | SMN1; SMN2MEN1KMT2ACYP2C19LMNA | |
| SCHEMBL14987039 | 0.76 | GLS (0.56) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL27796411 | 0.76 | SMARCA2 (0.51) | SMARCA2SMARCA4PBRM1SMN1; SMN2MEN1 | |
| SCHEMBL28794140 | 0.76 | SMN1; SMN2 (0.50) | SMARCA2SMARCA4PBRM1SMN1; SMN2MEN1 | |
| SCHEMBL31607953 | 0.75 | SMN1; SMN2 (0.50) | SMN1; SMN2MEN1KMT2ACYP2C19LMNA | |
| SCHEMBL30613376 | 0.75 | GAA (0.69) | SMARCA2SMARCA4PBRM1SMN1; SMN2MEN1 | |
| SCHEMBL2382922 | 0.75 | GAA (0.69) | SMARCA2SMARCA4PBRM1SMN1; SMN2MEN1 | |
| SCHEMBL15996763 | 0.75 | SMARCA2 (0.50) | SMARCA2SMARCA4PBRM1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0996446-B1 | NOVEL SUBSTITUTED IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2003-09-17 | — | — | EP | disclosed |
| US-6562832-B1 | Cytokine suppressive anti-inflammatory drugs, capable of inhibiting the CSBP/p38/RK kinase | SMITHKLINE BEECHAM CORPORATION | 2003-05-13 | — | — | US | disclosed |
| US-6046208-A | TREATMENT OF RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, ENDOTOXEMIA AND/OR TOXIC SHOCK SYNDROME, OTHER ACUTE OR CHRONIC INFLAMMATORY DISEASE STATES SUCH AS THE INFLAMMATORY REACTION INDUCED BY ENDOTOXIN OR INFLAMMATORY BOWEL DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 2000-04-04 | — | — | US | disclosed |