Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.55 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.52 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.52 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20339474 | 0.87 | GPR119 (0.55) | GPR119SMARCA2SMARCA4PBRM1MEN1 | |
| SCHEMBL354114 | 0.86 | L3MBTL1 (0.58) | GPR119MEN1KMT2APARP14ALDH1A1 | |
| SCHEMBL23073659 | 0.85 | GPR119 (0.53) | GPR119SMARCA2SMARCA4PBRM1MEN1 | |
| SCHEMBL6981354 | 0.82 | GPR119 (0.53) | GPR119SMARCA2SMARCA4PBRM1MEN1 | |
| SCHEMBL6950325 | 0.81 | SMARCA2 (0.49) | GPR119SMARCA2SMARCA4PBRM1MEN1 | |
| SCHEMBL13218466 | 0.81 | GPR119 (0.79) | GPR119MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL6495092 | 0.81 | PARP14 (0.59) | GPR119SMARCA2SMARCA4PBRM1MEN1 | |
| SCHEMBL30613376 | 0.78 | GAA (0.69) | GPR119SMARCA2SMARCA4PBRM1MEN1 | |
| SCHEMBL2382922 | 0.78 | GAA (0.69) | GPR119SMARCA2SMARCA4PBRM1MEN1 | |
| SCHEMBL25404908 | 0.78 | ALDH1A1 (0.70) | SMARCA2SMARCA4PBRM1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0996446-B1 | NOVEL SUBSTITUTED IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2003-09-17 | — | — | EP | disclosed |
| US-6562832-B1 | Cytokine suppressive anti-inflammatory drugs, capable of inhibiting the CSBP/p38/RK kinase | SMITHKLINE BEECHAM CORPORATION | 2003-05-13 | — | — | US | disclosed |
| US-6046208-A | TREATMENT OF RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, ENDOTOXEMIA AND/OR TOXIC SHOCK SYNDROME, OTHER ACUTE OR CHRONIC INFLAMMATORY DISEASE STATES SUCH AS THE INFLAMMATORY REACTION INDUCED BY ENDOTOXIN OR INFLAMMATORY BOWEL DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 2000-04-04 | — | — | US | disclosed |