Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 5/20 | 0.43 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 3/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | STS | P08842 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6959866 | 0.83 | KMT2A (0.46) | KMT2AALDH1A1LMNAMAPTCNR2 | |
| SCHEMBL6095235 | 0.81 | KMT2A (0.47) | KMT2AALDH1A1LMNAMAPTDRD2 | |
| SCHEMBL653312 | 0.81 | KMT2A (0.47) | KMT2AALDH1A1LMNAMAPTDRD2 | |
| SCHEMBL6095239 | 0.81 | KMT2A (0.47) | KMT2AALDH1A1LMNAMAPTDRD2 | |
| SCHEMBL8305744 | 0.81 | KMT2A (0.47) | KMT2AALDH1A1LMNAMAPTDRD2 | |
| SCHEMBL186884 | 0.81 | DRD2 (0.59) | KMT2AALDH1A1LMNAMAPTDRD2 | |
| SCHEMBL6954245 | 0.79 | ALDH1A1 (0.40) | KMT2AALDH1A1LMNAMAPTDRD2 | |
| SCHEMBL7076745 | 0.77 | OPRL1 (0.42) | KMT2AALDH1A1LMNAMAPTDRD2 | |
| SCHEMBL187383 | 0.76 | DRD2 (0.45) | KMT2ADRD2CCR1HSD11B1STS | |
| SCHEMBL373688 | 0.75 | DRD2 (0.45) | KMT2ADRD2CCR1HSD11B1STS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |