Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | PPIA | P62937 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6954245 | 0.87 | ALDH1A1 (0.40) | DRD2ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL6041529 | 0.80 | OPRL1 (0.47) | OPRL1MCHR1OPRK1DRD4ALDH1A1 | |
| SCHEMBL6950592 | 0.77 | KMT2A (0.44) | DRD2ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL7083199 | 0.75 | REN (0.46) | KMT2A | |
| SCHEMBL7080187 | 0.75 | CHRM3 (0.41) | PPIA | |
| SCHEMBL7082058 | 0.75 | REN (0.48) | — | |
| SCHEMBL6094891 | 0.74 | OPRK1 (0.40) | DRD2OPRK1KMT2A | |
| SCHEMBL8306369 | 0.74 | OPRK1 (0.40) | DRD2OPRK1KMT2A | |
| SCHEMBL6094894 | 0.74 | OPRK1 (0.40) | DRD2OPRK1KMT2A | |
| Tert-Butyl Formate SCHEMBL27562187 | 0.74 | SLC6A2 (0.42) | OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |