Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 4/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 4/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8092913 | 0.90 | SLC6A4 (0.38) | SLC6A4ADRA2AADRA2BADRA2CHTR2B | |
| Fumaric Acid SCHEMBL8092908 | 0.90 | SLC6A4 (0.38) | SLC6A4ADRA2AADRA2BADRA2CHTR2B | |
| SCHEMBL6949357 | 0.89 | SLC6A4 (0.56) | SLC6A4ADRA2AADRA2BADRA2CHTR2B | |
| SCHEMBL6950361 | 0.82 | CYP19A1 (0.46) | ADRA2AHTR1ACYP19A1 | |
| SCHEMBL14404061 | 0.79 | ADRA2A (0.36) | SLC6A4ADRA2AADRA2BADRA2CHTR2B | |
| SCHEMBL9635389 | 0.74 | SLC6A4 (0.44) | SLC6A4ADRA2AADRA2BADRA2CHTR2B | |
| Fumaric Acid SCHEMBL8097408 | 0.73 | CYP19A1 (0.38) | ADRA2AHTR1ACYP19A1 | |
| Fumaric Acid SCHEMBL8097411 | 0.73 | CYP19A1 (0.38) | ADRA2AHTR1ACYP19A1 | |
| SCHEMBL6959118 | 0.73 | SLC6A4 (0.38) | SLC6A4ADRA2AADRA2BADRA2CHTR2B | |
| SCHEMBL6960737 | 0.72 | ADRA2A (0.33) | SLC6A4ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1010693-B1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-09-24 | — | — | EP | disclosed |
| EP-1010693-A1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2000-06-21 | — | — | EP | disclosed |