Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PREP | P48147 | 4/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8097411 | 1.00 | CYP19A1 (0.38) | CYP19A1ADRA2AHTR1ASIGMAR1LMNA | |
| SCHEMBL6950361 | 0.89 | CYP19A1 (0.46) | CYP19A1ADRA2AHTR1ASIGMAR1GBA1 | |
| Fumaric Acid SCHEMBL8092913 | 0.86 | SLC6A4 (0.38) | CYP19A1ADRA2AHTR1A | |
| Fumaric Acid SCHEMBL8092908 | 0.86 | SLC6A4 (0.38) | CYP19A1ADRA2AHTR1A | |
| SCHEMBL6955604 | 0.79 | ADRA2A (0.49) | CYP19A1ADRA2A | |
| Fumaric Acid SCHEMBL8096777 | 0.78 | ADRA2A (0.42) | CYP19A1ADRA2ALMNABLM | |
| Fumaric Acid SCHEMBL8097796 | 0.78 | ADRA2A (0.42) | CYP19A1ADRA2ALMNABLM | |
| Fumaric Acid SCHEMBL8092366 | 0.78 | ADRA2A (0.42) | CYP19A1ADRA2ALMNABLM | |
| Fumaric Acid SCHEMBL8096772 | 0.78 | ADRA2A (0.42) | CYP19A1ADRA2ALMNABLM | |
| Fumaric Acid SCHEMBL8097801 | 0.78 | ADRA2A (0.42) | CYP19A1ADRA2ALMNABLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127396-A | Imidazoline compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |