Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 6/20 | 0.38 |
| ▸ | SLC6A2 known ✓ | P23975 | 4/20 | 0.33 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.31 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.31 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.31 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8092913 | 1.00 | SLC6A4 (0.38) | SLC6A4ADRA2AADRA2BADRA2CSLC6A2 | |
| SCHEMBL6950989 | 0.90 | SLC6A4 (0.45) | SLC6A4ADRA2AADRA2BADRA2CHDAC8 | |
| Fumaric Acid SCHEMBL8097411 | 0.86 | CYP19A1 (0.38) | ADRA2ACYP19A1HTR1A | |
| Fumaric Acid SCHEMBL8097408 | 0.86 | CYP19A1 (0.38) | ADRA2ACYP19A1HTR1A | |
| SCHEMBL6949357 | 0.81 | SLC6A4 (0.56) | SLC6A4ADRA2AADRA2BADRA2CHTR1A | |
| Fumaric Acid SCHEMBL8091705 | 0.78 | ALDH1A1 (0.33) | — | |
| Fumaric Acid SCHEMBL8091698 | 0.78 | ALDH1A1 (0.33) | — | |
| SCHEMBL6950361 | 0.74 | CYP19A1 (0.46) | ADRA2ACYP19A1HTR1A | |
| SCHEMBL8092912 | 0.74 | SLC6A4 (0.35) | SLC6A4ADRA2AADRA2BADRA2CHDAC8 | |
| Fumaric Acid SCHEMBL8097507 | 0.73 | ADRA2A (0.50) | ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127396-A | Imidazoline compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |