Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 8/20 | 0.38 |
| ▸ | BCHE | P06276 | 6/20 | 0.38 |
| ▸ | FAAH | O00519 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 5/20 | 0.38 |
| ▸ | HTR7 | P34969 | 5/20 | 0.38 |
| ▸ | DRD2 | P14416 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3505067 | 0.90 | ACHE (0.40) | ACHEBCHEFAAHHTR2ADRD2 | |
| SCHEMBL8947062 | 0.88 | ACHE (0.42) | ACHEBCHEFAAHALDH1A1 | |
| SCHEMBL6956988 | 0.84 | ACHE (0.47) | ACHEBCHEFAAHALDH1A1 | |
| SCHEMBL3505500 | 0.82 | ALDH1A1 (0.43) | ACHEBCHEALDH1A1 | |
| SCHEMBL6956977 | 0.81 | ACHE (0.39) | MEN1KMT2AACHEBCHEHTR2A | |
| SCHEMBL6951018 | 0.80 | HRH3 (0.45) | HRH3MEN1KMT2AACHEALDH1A1 | |
| SCHEMBL9085384 | 0.80 | POLB (0.47) | ALDH1A1EPHX2 | |
| SCHEMBL3507456 | 0.79 | EPHX2 (0.41) | ACHEBCHEFAAHALDH1A1EPHX2 | |
| SCHEMBL3508760 | 0.78 | HTR2A (0.39) | HTR2AHTR7DRD2ALDH1A1KCNH2 | |
| SCHEMBL3504376 | 0.77 | GRM4 (0.41) | ACHEHTR2AHTR7ALDH1A1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0669920-B1 | SUBSTITUTED 3-(AMINOALKYLAMINO)-1,2-BENZISOXAZOLES AND RELATED COMPOUNDS | AVENTIS PHARMA INC (US) | 2003-02-12 | — | — | EP | disclosed |
| US-6046203-A | USEFUL FOR THE TREATMENT OF VARIOUS MEMORY DYSFUNCTIONS CHARACTERIZED BY A DECREASED CHOLINERGIC FUNCTION SUCH AS ALZHEIMER'S DISEASE; ALSO INHIBIT MONOAMINE OXIDASE AND HENCE ARE USEFUL AS ANTIDEPRESSANTS | AVENTIS PHARMACEUTICALS INC. (US) | 2000-04-04 | — | — | US | disclosed |
| US-5580982-A | ANTIDEPRESSANTS; ANTICHOLINERGIC AGENTS; ALZHEIMER'S DISEASE; AMINE OXIDASE INHIBITORS | HOECHST MARION ROUSSEL INC. (US) | 1996-12-03 | — | — | US | disclosed |
| US-5494908-A | ANTIDEPRESSANT | HOECHST-ROUSSEL PHARMACEUTICAL INCORPORATED (US) | 1996-02-27 | — | — | US | disclosed |
| EP-0673946-A2 | Metallocenes and their use in polymerization of olefins | PCD-Polymere Gesellschaft m.b.H. (AT) | 1995-09-27 | — | — | EP | disclosed |