Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.34 |
| ▸ | MPO | P05164 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 3/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8091522 | 0.90 | HRH3 (0.35) | ADRA2ACHRM2CHRM4CHRM5CHRM1 | |
| Fumaric Acid SCHEMBL8091527 | 0.90 | HRH3 (0.35) | ADRA2ACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL6951696 | 0.82 | ADRA2A (0.56) | ADRA2AHTR1AHTR2B | |
| SCHEMBL6957391 | 0.74 | SLC6A2 (0.39) | ADRA2AMPO | |
| Fumaric Acid SCHEMBL8092928 | 0.73 | ADRA2A (0.46) | ADRA2AHTR1AHTR2BCA12CA1 | |
| Fumaric Acid SCHEMBL8092925 | 0.73 | ADRA2A (0.46) | ADRA2AHTR1AHTR2BCA12CA1 | |
| SCHEMBL8091525 | 0.70 | HDAC3 (0.35) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL1258244 | 0.69 | POLB (0.43) | ADRA2ACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL1258242 | 0.69 | POLB (0.43) | ADRA2ACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL20559454 | 0.67 | LOXL2 (0.58) | CHRM2CHRM4CHRM5CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1010693-B1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-09-24 | — | — | EP | disclosed |
| EP-1010693-A1 | Imidazoline derivatives, preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2000-06-21 | — | — | EP | disclosed |