Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.36 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.35 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.35 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.35 |
| ▸ | FLT3 known ✓ | P36888 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | PREP | P48147 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8092928 | 1.00 | ADRA2A (0.46) | ADRA2APREPLOXL2PIN1HTR1A | |
| SCHEMBL6951696 | 0.89 | ADRA2A (0.56) | ADRA2APREPLOXL2HTR1AHTR2B | |
| Fumaric Acid SCHEMBL8091522 | 0.86 | HRH3 (0.35) | ADRA2AHTR1AHTR2BKDM4EMAPT | |
| Fumaric Acid SCHEMBL8091527 | 0.86 | HRH3 (0.35) | ADRA2AHTR1AHTR2BKDM4EMAPT | |
| Fumaric Acid SCHEMBL8084695 | 0.78 | TBXA2R (0.43) | CYP2D6SLC6A2SLC6A4SLC6A3KCNH2 | |
| Fumaric Acid SCHEMBL8084690 | 0.78 | TBXA2R (0.43) | CYP2D6SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL6951243 | 0.73 | ADRA2A (0.38) | ADRA2AHTR1AHTR2BCA12CA1 | |
| Fumaric Acid SCHEMBL8093570 | 0.70 | ADRA2A (0.49) | ADRA2AALDH1A1CYP2D6 | |
| Fumaric Acid SCHEMBL8093564 | 0.70 | ADRA2A (0.49) | ADRA2AALDH1A1CYP2D6 | |
| SCHEMBL4828390 | 0.69 | LOXL2 (0.49) | LOXL2PIN1HTR1AHTR2BESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1183907-C | Imidazoline compound, preparing process thereof and pharmaceutical composition contg. same | SERVIER LAB (FR) | 2005-01-12 | — | — | CN | disclosed |
| US-6127396-A | Imidazoline compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |