Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 10/20 | 0.40 |
| ▸ | MMP2 | P08253 | 10/20 | 0.40 |
| ▸ | MMP13 | P45452 | 9/20 | 0.40 |
| ▸ | MMP9 | P14780 | 8/20 | 0.40 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.37 |
| ▸ | MMP1 | P03956 | 10/20 | 0.36 |
| ▸ | MMP7 | P09237 | 2/20 | 0.36 |
| ▸ | MMP14 | P50281 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.34 |
| ▸ | MMP8 | P22894 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7221727 | 0.87 | MMP2 (0.37) | MMP3MMP2MMP13MMP9PLA2G7 | |
| SCHEMBL6946388 | 0.85 | MMP2 (0.40) | MMP3MMP2MMP13MMP9PLA2G7 | |
| SCHEMBL6945448 | 0.84 | MMP2 (0.39) | MMP3MMP2MMP13MMP9PLA2G7 | |
| Hydrochloric Acid SCHEMBL7425983 | 0.83 | MMP2 (0.38) | MMP3MMP2MMP13MMP9PLA2G7 | |
| SCHEMBL6946612 | 0.83 | MMP3 (0.38) | MMP3MMP2MMP13MMP9PLA2G7 | |
| SCHEMBL7078769 | 0.79 | MMP2 (0.36) | MMP3MMP2MMP13MMP9PLA2G7 | |
| SCHEMBL6949966 | 0.74 | PLA2G7 (0.44) | MMP3MMP2MMP13MMP9PLA2G7 | |
| SCHEMBL7078766 | 0.73 | MMP2 (0.36) | MMP3MMP2MMP13MMP9PLA2G7 | |
| SCHEMBL6948972 | 0.71 | PLA2G7 (0.52) | MMP3MMP2MMP13MMP9PLA2G7 | |
| SCHEMBL6952582 | 0.71 | MMP2 (0.38) | MMP3MMP2MMP13MMP9PLA2G7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030836-B1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LTD (GB) | 2003-01-29 | — | — | EP | disclosed |
| US-6187924-B1 | INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TUMOR NECROSIS FACTOR-ALPHA-MEDIATED DISEASES | DARWIN DISCOVERY, LTD. (GB) | 2001-02-13 | — | — | US | disclosed |